Calculator

MMCD score to predict risk of KRT needed in COVID-19

Estimates in-hospital KRT needed in patients admitted for COVID-19.

Information

When to use?

At admission in the hospital, to stratify the in-hospital KRT needed risk of COVID-19 patients.

How was it developed and validated?

Based in a cohort of 5,212 patients from 35 hospitals, from 17 cities in Brazil,following strict methodological criteria.

Why to use?

  • It is easily calculated at bedside at admission.
  • It identifies three categories at increasing risk of KRT requirement with a high level of accuracy.
  • It may help healthcare practitioners to better identify patients with higher risk of KRT requirement and it may help to organize resource allocation to patients who are at the highest risk of KRT requirement.

How it should be used?

Only in-hospital patients, through the use of variables easily accessible at admission.

How it should not be used?

  • It should not be considered a medical device.
  • It should not be used with pregnant or pediatric patients.
  • It was validated in a cohort of Brazilian patients, and it should not be adopted for routine clinical use in other settings until it has been appropriately externally validated in those settings.

Calculator

VariableMMCD Score
$M$$M$echanical ventilation anytime during hospital stay$^a$
No0
Yes11
$M$$M$ale sex
No0
Yes1
$C$$C$reatinine (mg/dL) upon hopistal presentation
$\lt$ 1.20
1.2 - 2.01
2.0 - 3.52
3.5 - 5.04
$\geqslant$ 5.010
$D$$D$iabetes mellitus
No0
Yes1

Publications

Publication: de Azevedo Figueiredo, F., Ramos, L. E. F., Silva, R. T., Pires, M. C., Ponce, D., de Carvalho, R. L. R., … & Marcolino, M. S. (2022). Development and validation of the MMCD score to predict kidney replacement therapy in COVID-19 patients. medRxiv. https://www.medrxiv.org/content/10.1101/2022.01.11.22268631v1

Team

Flávio de Azevedo Figueiredo$^{1,2}$, Lucas Emanuel Ferreira Ramos$^3$, Rafael Tavares Silva$^3$, Magda Carvalho Pires$^3$, Daniela Ponce$^{4}$, Rafael Lima Rodrigues de Carvalho$^{24}$, Alexandre Vargas Schwarzbold$^5$, Amanda de Oliveira Maurílio$^6$, Ana Luiza Bahia Alves Scotton$^7$, Andresa Fontoura Garbini$^8$, Bárbara Lopes Farace$^9$, Bárbara Machado Garcia$^{10}$, Carla Thais Cândida Alves da Silva$^{11}$, Christiane Corrêa Rodrigues Cimini$^{12,13}$, Cíntia Alcantara de Carvalho$^{14}$, Cristiane dos Santos Dias$^{15}$, Daniel Vitorio Silveira$^{16}$, Euler Roberto Fernandes Manenti$^{17}$, Evelin Paola de Almeida Cenci$^{18}$, Fernando Anschau$^{18}$, Fernando Graça Aranha$^{19}$, Filipe Carrilho de Aguiar$^{20}$, Frederico Bartolazzi$^{11}$, Giovanna Grunewald Vietta$^{19}$ MD, Guilherme Fagundes Nascimento$^{16}$, Helena Carolina Noal$^{5}$, Helena Duani$^{21}$, Heloisa Reniers Vianna$^{22}$, Henrique Cerqueira Guimarães$^{9}$, Joice Coutinho de Alvarenga$^{14}$, José Miguel Chatkin$^{23}$, Júlia Parreiras Drumond de Moraes$^{22}$, Juliana Machado Rugolo$^{4}$, Karen Brasil Ruschel$^{17,24}$, Karina Paula Medeiros Prado Martins$^{21, 24}$, Luanna Silva Monteiro Menezes$^{25,26}$, Luciana Siuves Ferreira Couto$^{25}$, Luís César de Castro$^{28}$, Luiz Antônio Nasi$^{27}$, Máderson Alvares de Souza Cabral$^{21}$, Maiara Anschau Floriani$^{27}$, Maíra Dias Souza$^{26}$, Maira Viana Rego Souza e Silva$^{1}$, Marcelo Carneiro$^{29}$, Mariana Frizzo de Godoy$^{23}$, Maria Aparecida Camargos Bicalho$^{10}$, Maria Clara Pontello Barbosa Lima$^{30}$ , Matheus Carvalho Alves Nogueira$^{31}$, Matheus Fernandes Lopes Martins$^{32}$, Milton Henriques Guimarães Júnior$^{32}$, Natália da Cunha Severino Sampaio$^{33}$, Neimy Ramos de Oliveira$^{33}$, Patricia Klarmann Ziegelmann$^{24,34}$, Pedro Guido Soares Andrade$^{35}$, Pedro Ledic Assaf$^{36}$, Petrônio José de Lima Martelli$^{20}$, Polianna Delfino Pereira$^{1,14}$, Raphael Castro Martins$^{34}$, Rochele Mosmann Menezes$^{29}$, Saionara Cristina Francisco$^{36}$, Silvia Ferreira Araújo$^{35}$, Talita Fischer Oliveira$^{26}$, Thainara Conceição de Oliveira$^{18}$, Thaís Lorenna Souza Sales$^{24,37}$, Yuri Carlotto Ramires$^{28}$, Milena Soriano Marcolino$^{1,21,24,38}$


$^1$Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil. $^{2}$Department of Medicine, Universidade Federal de Lavras. Aquenta Sol, Lavras, Brazil. $^{3}$Department of Statistics, Universidade Federal de Minas Gerais. Av. Presidente Antônio Carlos, 6627, Belo Horizonte, Brazil. $^{4}$Botucatu Medical School, Universidade Estadual Paulista “Júlio de Mesquita Filho”. Av. Prof. Mário Rubens Guimarães Montenegro, Botucatu, Brazil. $^{5}$Hospital Universitário de Santa Maria. Av. Roraima, 1000, Santa Maria, Brazil. $^{6}$Hospital São João de Deus. R. do Cobre, 800, Divinópolis, Brazil. $^{7}$Hospital Regional Antônio Dias. R. Maj. Gote, 1231, Patos de Minas, Brazil. $^{8}$Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Av. Francisco Trein, 326, Porto Alegre, Brazil. $^{9}$Hospital Risoleta Tolentino Neves. R. das Gabirobas, 01, Belo Horizonte, Brazil. $^{10}$0Hospital Júlia Kubitschek. Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil. $^{11}$1Hospital Santo Antônio. Praça Dr. Márcio Carvalho Lopes Filho, 501, Curvelo, Brazil. $^{12}$Hospital Santa Rosália. R. do Cruzeiro, 01, Teófilo Otoni, Brazil. $^{13}$Mucuri Medical School, Universidade Federal dos Vales do Jequitinhonha e Mucuri. R. Cruzeiro, 01, Teófilo Otoni, Brazil. $^{14}$Hospital João XXIII. Av. Professor Alfredo Balena, 400, Belo Horizonte, Brazil. $^{15}$Department of Pediatrics, Medical School, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil. $^{16}$Hospital UNIMED BH. Av. do Contorno, 3097, Belo Horizonte, Brazil. $^{17}$Hospital Mãe de Deus. R. José de Alencar, 286, Porto Alegre, Brazil. $^{18}$Hospital Universitário Canoas. Av. Farroupilha, 8001, Canoas, Brazil. $^{19}$Hospital SOS Cárdio. Rodovia, SC-401, 121, Florianópolis, Brazil. $^{20}$Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235, Recife, Brazil. $^{21}$Medical School and University Hospital, Universidade Federal de Minas Gerais. Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil. $^{22}$Hospital Universitário Ciências Médicas. R. dos Aimorés, 2896, Belo Horizonte, Brazil. $^{23}$Hospital São Lucas da PUCRS. Av. Ipiranga, 6690, Porto Alegre, Brazil. $^{24}$Institute for Health Technology Assessment (IATS/ CNPq). R. Ramiro Barcelos, 2359, Porto Alegre, Brazil. $^{25}$Hospital Luxemburgo. R. Gentios, 1350, Belo Horizonte, Brazil. $^{26}$Hospital Metropolitano Odilon Behrens. R. Formiga, 50, Belo Horizonte, Brazil. $^{27}$Hospital Moinhos de Vento. R. Ramiro Barcelos, 910, Porto Alegre, Brazil. $^{28}$Hospital Bruno Born. Av. Benjamin Constant, 881, Lajeado, Brazil. $^{29}$Hospital Santa Cruz. R. Fernando Abott, 174, Santa Cruz do Sul, Brazil. $^{30}$Medical School, Universidade Federal de Ouro Preto. R. Diogo de Vasconcelos, 122, Ouro Preto, Brazil. $^{31}$Hospitais da Rede Mater Dei. Av. do Contorno, 9000, Belo Horizonte, Brazil. $^{32}$Hospital Márcio Cunha. Av. Kiyoshi Tsunawaki, 48, Ipatinga, Brazil. $^{33}$Hospital Eduardo de Menezes. R. Dr. Cristiano Rezende, 2213, Belo Horizonte, Brazil. $^{34}$Hospital Tacchini. R. Dr. José Mário Mônaco, 358, Bento Gonçalves, Brazil. $^{35}$Hospital Semper. Alameda Ezequiel Dias, 389, Belo Horizonte, Brazil. $^{36}$Hospital Metropolitano Doutor Célio de Castro. R. Dona Luiza, 311, Belo Horizonte, Brazil. $^{37}$Universidade Federal de São João del-Rei. R. Sebastião Gonçalves Coelho, 400, Divinópolis, Brazil. $^{38}$Telehealth Center, University Hospital, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena, 110, Belo Horizonte, Brazil.

Contact

  • milenamarc@ufmg.br
  • +55 3133079201
  • 110, Professor Alfredo Balena Avenue, Belo Horizonte, Minas Gerais, Brazil, 30130-100
  • Telehealth Center, University Hospital, Universidade Federal de Minas Gerais
  • Monday to Friday 7:00 to 19:00
    UTC/GMT -03:00